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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 116-122 doi: 10.1007/s11705-013-1310-0

Abstract: acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drugIn addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium.This may be attributed to Fickian diffusion since the drug and the medium in which it was released have

Keywords： psyllium     acetyl salicylic acid     in-vitro drug release     swelling     biodegradation    

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Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 1-1 doi: 10.1007/s11705-009-0306-2

Abstract:
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Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 624-632 doi: 10.1007/s11705-017-1614-6

Abstract: Platelets dynamically participate in various physiological processes, including wound repair, bacterial clearance, immune response, and tumor metastasis. Recreating the specific biological features of platelets by mimicking the structure of the platelet or translocating the platelet membrane to synthetic particles holds great promise in disease treatment. This review highlights recent advancements made in the platelet-mimicking strategies. The future opportunities and translational challenges are also discussed.

Keywords： drug delivery     platelets     nanomedicine     bio-inspired     biomimetic    

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Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4,   Pages 483-489 doi: 10.1007/s11705-022-2227-2

Abstract: Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process, the bioorthogonal reaction that commonly contains the “bond formation” and “bond cleavage” system has been widely used in targeted therapy for a variety of tumors. Herein, several prominent cases based on the bioorthogonal reaction that tailoring the metabolic glycoengineering tactics to modified cells for cancer immunotherapy, and the innovative tactics for reducing the metal ions’ toxic and side effects with microneedle patches will be highlighted. Based on these applications, the complexities, potential pitfalls, and opportunities of bioorthogonal chemistry in future cancer therapy will be evaluated.

Keywords： bioorthogonal reaction     cancer therapy     metabolic glycoengineering     bioorthogonal catalytic patch    

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Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 276-279 doi: 10.1007/s11705-014-1426-x

Abstract: The drug delivery scientists need to reexamine the advances made during the past 60 years, analyze ourThe ultimate goal of drug delivery research is to develop clinically useful formulations to treat variousEffective drug delivery systems can be developed by overcoming formulation barriers and/or biologicalso that they can be overcome by engineering manipulation of the drug delivery systems.The new generation of drug delivery scientists needs to be aware of the successes and limitations of

Keywords： drug delivery     history     formulation barriers     nanotechnology     clinical product    

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Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2,   Pages 221-237 doi: 10.1007/s11705-020-1927-8

Abstract: review focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drugdelivery.The potential risks of using ZIF-8 for drug delivery are also summarized.

Keywords： zeolitic imidazolate framework-8 (ZIF-8)     synthesis methods     applications     drug delivery    

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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: These polymers are selected based on their importance and broad scope of application in FDA-approved drugGlyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussedand advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery

Keywords： controlled release     drug delivery     semi-solids     polymer     excipient    

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Konjac glucomannan and xanthan gum as compression coat for colonic drug delivery: experimental and theoretical

Kang WANG, Jiangyang FAN, Yanjun LIU, Zhimin HE,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 102-108 doi: 10.1007/s11705-009-0299-x

Abstract: Compression coated tablets for oral colon specific delivery systems were developed with a mixture polysaccharideresults indicate that a KGM70 tablet with a 0.4g coat is of good design, due to a less than 5% drugThe release mechanism and model are discussed based on different periods of drug release including thedelay of the drug, the constant release without an enzyme and the delay of degradation.Under hydrolysis by -mannanase, drug release from the tablet with KGM coat shows an exponential increase
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Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 667-677 doi: 10.1007/s11684-017-0583-y

Abstract: platelets in cancer progression and metastasis provides promising approaches for platelet biomimetic drugdelivery systems and functional platelet-targeting strategies for effective cancer treatment.This review highlights recent progresses in platelet membrane-based drug delivery and unique strategies

Keywords： platelet-mimicking delivery systems     tumor-associated platelets     cancer therapy     EPR effect    

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Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 1,   Pages 1-14 doi: 10.1007/s11705-015-1509-3

Abstract: development of modern technology like high throughput screening, combinatorial chemistry and computer aid drugdesign, the drug discovery process has been dramatically accelerated.However, new drug candidates often exhibit poor aqueous or even organic medium solubility.Nanocrystal formulation sheds new light on advanced drug development.to be a novel drug delivery system for specific diseases (i.e. cancer).

Keywords： drug nanocrystal     nanotechnology     formulation     bioavailability     stabilizers     drug delivery    

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Barriers to advancing nanotechnology to better improve and translate nanomedicines

Yuwei WANG,David W. Grainger

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 265-275 doi: 10.1007/s11705-014-1442-x

Abstract: Engineered nanomaterials and nanotechnologies promise many benefits to enhance both and performance. This is now manifest in the increasing number of reported biomedical products under development and testing that contain nanotechnologies as their distinguishing performance—enhancing components. In many cases, nano-sized materials are selected to provide a specific functional aspect that contributes to improved medical performance, either or . Nanoparticles are most commonly exploited in diverse roles in topical lotions and creams, solubilization aids, for and diagnostic and targeting agents in nanomedicines and theranostics. Despite fundamental scientific excitement and many claims to nanotechnology-based improvements in new biomedical applications, several fundamental and long-standing challenges remain to be addressed using nanomedicines to make clinically important progress. This review addresses several issues that must be fairly and objectively reported and then overcome to provide truly credible performance for nanomedicines.

Keywords： nanotechnology     nanomedicine     drug delivery     therapeutic     target delivery    

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Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 529-536 doi: 10.1007/s11705-017-1645-z

Abstract: An anticancer drug delivery system consisting of DNA nanoparticles synthesized by rolling circle amplificationThe template of RCA was a DNA oligodeoxynucleotide coded with PSMA-targeted aptamer, drug-loading domainAnticancer drug doxorubicin, as the model drug, was loaded into the drug-loading domain (multiple GC-pairenvironment, the cumulative release of doxorubicin was far more than the cumulative release of the drugThe prepared DNA nanoparticles showed the potential as drug delivery system for PSMA targeting prostate

Keywords： aptamer     DNA nanoparticles     rolling circle amplification     doxorubicin     drug delivery     pH sensitive    

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3D Photo-Fabrication for Tissue Engineering and Drug Delivery Review

Rúben F. Pereira, Paulo J. Bártolo

Engineering 2015, Volume 1, Issue 1,   Pages 90-112 doi: 10.15302/J-ENG-2015015

Abstract: to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and deliverythe use of 3D photo-fabrication techniques to produce advanced constructs for tissue regeneration and drugdelivery applications.capable of providing appropriate environments for tissue regeneration, and regulating the spatiotemporal delivery

Keywords： 3D photo-fabrication     biomaterials     tissue engineering     drug delivery    

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Iron oxide nanoparticle-based theranostics for cancer imaging and therapy

Xiaoqing REN,Hongwei CHEN,Victor YANG,Duxin SUN

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 253-264 doi: 10.1007/s11705-014-1425-y

Abstract: imaging (MRI), multimodal imaging, chemotherapy, hyperthermal therapy, photodynamic therapy, and gene delivery

Keywords： theranostics     iron oxide nanoparticles     MRI     drug delivery     photothermal therapy     photodynamic therapy    

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Functional ferritin nanoparticles for biomedical applications

Zhantong Wang, Haiyan Gao, Yang Zhang, Gang Liu, Gang Niu, Xiaoyuan Chen

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 633-646 doi: 10.1007/s11705-017-1620-8

Abstract: This review will highlight the recent advances in ferritin nanoparticles for drug delivery, bioassay,

Keywords： nanomedicine     ferritin     drug delivery     bioassay     molecular imaging    

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Title Author Date Type Operation

Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

Journal Article

Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

Journal Article

Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

Journal Article

Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

Journal Article

Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

Journal Article

Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

Journal Article

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Journal Article

Konjac glucomannan and xanthan gum as compression coat for colonic drug delivery: experimental and theoretical

Kang WANG, Jiangyang FAN, Yanjun LIU, Zhimin HE,

Journal Article

Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy

Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie

Journal Article

Nanocrystal technology for drug formulation and delivery

Tzu-Lan CHANG, Honglei ZHAN, Danni LIANG, Jun F. LIANG

Journal Article

Barriers to advancing nanotechnology to better improve and translate nanomedicines

Yuwei WANG,David W. Grainger

Journal Article

Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

Pengwei Zhang, Junxiao Ye, Ergang Liu, Lu Sun, Jiacheng Zhang, Seung Jin Lee, Junbo Gong, Huining He, Victor C. Yang

Journal Article

3D Photo-Fabrication for Tissue Engineering and Drug Delivery

Rúben F. Pereira, Paulo J. Bártolo

Journal Article

Iron oxide nanoparticle-based theranostics for cancer imaging and therapy

Xiaoqing REN,Hongwei CHEN,Victor YANG,Duxin SUN

Journal Article

Functional ferritin nanoparticles for biomedical applications

Zhantong Wang, Haiyan Gao, Yang Zhang, Gang Liu, Gang Niu, Xiaoyuan Chen

Journal Article